The Aesthetics of Ambiguity: Understanding and Addressing Monoculture has been produced to coincide with the exhibition: Monoculture: A Recent History, on show at M HKA from 25 September 2020 – 24 January 2021. The publication is presented in the framework of ‘Our Many Europes’, a four-year (2018-2022) EU funded programme organized by the museum confederation L’Internationale, that brings together seven major European Art institutions. This book gives stage to artists, thinkers and institutional practices who dare to play with the rules of a broader society and thus generate ambiguity ‘at large’. The book represents a quest for (more) ambiguity in order to avoid rigid borders or black-and-white polarities between cultures, as well as between practices of art and scientific thinking. By doing so, the artists, activists and researchers featured in this book plea for a politics and aesthetics of ambiguity to deal with the complexity of our living together on Earth.